GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs5758659 | 1 | rs5758660 | chr22:42623718 | CCDC134 | chr22:42196678-42222303:+ | 0.21 | 4.09 | 5.17E-5 | Cognitive function |
| THCA | cis | rs5758659 | 1 | rs5758660 | chr22:42623718 | CYP2D6 | chr22:42522502-42526883:- | -0.41 | -10.57 | 1.3E-23 | Cognitive function |
| THCA | cis | rs5758659 | 1 | rs5758660 | chr22:42623718 | NAGA | chr22:42454339-42466846:- | 0.36 | 7.73 | 6.33E-14 | Cognitive function |
| THCA | cis | rs5758659 | 1 | rs5758660 | chr22:42623718 | WBP2NL | chr22:42120334-42454460:+ | 0.25 | 4.53 | 7.29E-6 | Cognitive function |
| THCA | cis | rs5758659 | 1 | rs5758677 | chr22:42643039 | C22orf32 | chr22:42475699-42480287:+ | 0.2 | 5.22 | 2.69E-7 | Cognitive function |
| THCA | cis | rs5758659 | 1 | rs5758677 | chr22:42643039 | CCDC134 | chr22:42196678-42222303:+ | 0.21 | 3.98 | 8.0E-5 | Cognitive function |
| THCA | cis | rs5758659 | 1 | rs5758677 | chr22:42643039 | CYP2D6 | chr22:42522502-42526883:- | -0.41 | -10.76 | 2.44E-24 | Cognitive function |
| THCA | cis | rs5758659 | 1 | rs5758677 | chr22:42643039 | NAGA | chr22:42454339-42466846:- | 0.34 | 7.42 | 5.57E-13 | Cognitive function |
| THCA | cis | rs5758659 | 1 | rs5758677 | chr22:42643039 | WBP2NL | chr22:42120334-42454460:+ | 0.24 | 4.5 | 8.45E-6 | Cognitive function |
| THCA | cis | rs2072883 | 1 | rs5759113 | chr22:43443952 | ARFGAP3 | chr22:43192532-43253408:- | 0.22 | 4.86 | 1.61E-6 | Schizophrenia |
| THCA | cis | rs4820539 | 1 | rs5759595 | chr22:23471624 | GNAZ | chr22:23412669-23467221:+ | -0.25 | -5.4 | 1.05E-7 | Bone mineral density |
| THCA | cis | rs4820539 | 1 | rs5759596 | chr22:23475750 | GNAZ | chr22:23412669-23467221:+ | -0.25 | -5.36 | 1.26E-7 | Bone mineral density |
| THCA | cis | rs4820539 | 1 | rs5759598 | chr22:23480962 | GNAZ | chr22:23412669-23467221:+ | -0.26 | -5.66 | 2.55E-8 | Bone mineral density |
| THCA | cis | rs4820539 | 1 | rs5759598 | chr22:23480962 | RAB36 | chr22:23487513-23506531:+ | 0.18 | 3.5 | 0.0005 | Bone mineral density |
| THCA | cis | rs8141797 | 1 | rs5760216 | chr22:24539734 | SUSD2 | chr22:24577444-24585074:+ | 0.29 | 3.4 | 0.000731 | Amyotrophic lateral sclerosis |